JPE-1375 [1254036-23-1]

MedChem Express

JPE-1375 [1254036-23-1]

10

1254036-23-1

Research Use Only

99.96

C49H63FN10O9

955.08

JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 microM) and reduces TNF levels (EC50=4.5 microM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases[1].

O=C([C@@H]1CC(NC(N1)=O)=O)N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCN)C(N3[C@@H](CCC3)C(N[C@@H](CCC(C)C)C(N[C@H](C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)CC5=CC=C(C=C5)F)=O)=O)=O)=O

2°C to 8°C

12352200