JPE-1375

MedChem Express

JPE-1375

10

Research Use Only

99.94

C49H63FN10O9

955.08

JPE-1375 is a complement C5a receptor 1 ( C5aR1 ) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization ( EC 50 =6.9 microM) and reduces TNF levels ( EC 50 =4.5 microM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases [1] .

O=C([C@@H]1CC(NC(N1)=O)=O)N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCN)C(N3[C@@H](CCC3)C(N[C@@H](CCC(C)C)C(N[C@H](C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)CC5=CC=C(C=C5)F)=O)=O)=O)=O

2°C to 8°C

12352200