WB analysis of 293 cell lysate in (A) the absence and (B) the presence of blocking peptide using GTX85367 JPH2 antibody. Working concentration : 2 microg/ml
WB analysis of 293 cell lysate in (A) the absence and (B) the presence of blocking peptide using GTX85367 JPH2 antibody. Working concentration : 2 microg/ml
JPH2 antibody
GTX85367
Overview
- SupplierGeneTex
- Product NameJPH2 antibody
- Delivery Days Customer9
- Antibody SpecificityThis antibody is specific for JPH2 C-Terminus
- Application Supplier NoteWB: 2 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- Concentration1 mg/ml
- FormulationLiquid
- Gene ID57158
- Target nameJPH2
- Target descriptionjunctophilin 2
- Target synonymsCMD2E; CMH17; JP2; JP-2; junctophilin type 2; junctophilin-2
- Protein IDQ9BR39
- Protein NameJunctophilin-2
- Scientific DescriptionJunctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH2- mice died of embryonic cardiac arrest and human patients with mutations in the JPH2 gene showed hypertrophic cardiomyopathy, demonstrating the importance of this protein. Multiple isoforms of JPH2 are known to exist.
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203