Bio-Connect

JPS016 (TFA)

HY-145816A
MedChem Express
Estimated Purity98.70
Product group Chemicals
Molecular Weight1012.14
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Overview

  • Supplier
    MedChem Express
  • Product Name
    JPS016 (TFA)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    98.70
  • Molecular Formula
    C50H64F3N7O10S
  • Molecular Weight
    1012.14
  • Scientific Description
    JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS016 degrades class I histone deacetylase (HDAC). JPS016 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells [1] .
  • SMILES
    O=C(N(C[C@@H]1O)[C@@H](C1)C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCCCCCCCCOCC(NC(C=C4)=CC=C4C(NC(C=CC=C5)=C5N)=O)=O)=O.OC(C(F)(F)F)=O
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200