JPS016 (TFA)
HY-145816A
Overview
- SupplierMedChem Express
- Product NameJPS016 (TFA)
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity98.70
- Molecular FormulaC50H64F3N7O10S
- Molecular Weight1012.14
- Scientific DescriptionJPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS016 degrades class I histone deacetylase (HDAC). JPS016 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells [1] .
- SMILESO=C(N(C[C@@H]1O)[C@@H](C1)C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCCCCCCCCOCC(NC(C=C4)=CC=C4C(NC(C=CC=C5)=C5N)=O)=O)=O.OC(C(F)(F)F)=O
- Storage Instruction-20°C
- UNSPSC12352200