JS25 [2411771-95-2]

MedChem Express

JS25 [2411771-95-2]

10

2411771-95-2

Research Use Only

98.37

C29H24N4O4S

524.59

JS25 is a selective and covalent inhibitor of BTK that inactivates BTK with an IC50 value of 5.8 nM by chelating Tyr551. JS25 inhibits cancer cells proliferation, pronounces cell death, and promotes murine xenograft model of Burkitts lymphoma. JS25 effectively crosses the blood-brain barrier[1].

C=CC(NC1=CC(C)=CC(N2C(C=CC3=C2C4=C(N=C3)C=C(C=C4)C5=CC=C(C=C5)NS(C)(=O)=O)=O)=C1)=O

2°C to 8°C

12131703