JWJ-01-306

MedChem Express

JWJ-01-306

5

Research Use Only

C28H26ClF3N4O4

574.98

JWJ-01-306 is a molecular glue that targets the C 2 H 2 zinc finger transcription factor ZBTB11 . JWJ-01-306 degrades ZBTB11, reduces the oxidative phosphorylation (OXPHOS) and tricarboxylic acid (TCA) cycle, and inhibits the proliferation of KAS-resistant PDAC cells. JWJ-01-306 exhibits good pharmacokinetic characteristics in mouse model [1] .

FC(F)(F)C1=C(Cl)C=CC(CCNC2(CCC2)C3=CC(NC(C(N4C5CCC(NC5=O)=O)=O)=CC4=O)=CC=C3)=C1

12352200