K-Ras ligand-Linker Conjugate 1

MedChem Express

K-Ras ligand-Linker Conjugate 1

10

Research Use Only

K-Ras ligand-Linker Conjugate 1 incorporates a ligand for K-Ras , and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 1 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells [1] .

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