K-Ras ligand-Linker Conjugate 2

TargetMol Chemicals

K-Ras ligand-Linker Conjugate 2

9

Chemical

Research Use Only

K-Ras ligand-Linker Conjugate 2

C45H58N8O7

822.99

K-Ras ligand-Linker Conjugate 2 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker, capable of recruiting E3 ligases like VHL, CRBN, MDM2, and IAP. It is utilized in synthesizing PROTAC K-Ras Degrader-1, a highly effective PROTAC K-Ras degrader with a degradation efficacy of ≥70% in SW1573 cells[1].

3 years

NCCOCCOCCOCCO[C@H]1CN(C)[C@H](COC2=NC3=C(CCN(C4=CC=CC5=C4C=CC=C5)C3)C(N6CCN(C(OCC7=CC=CC=C7)=O)[C@@H](CC#N)C6)=N2)C1

-20°C

12352200