K67

MedChem Express

K67

10

Research Use Only

98.43

C29H30N2O7S2

582.69

K67 is a selective the interaction between Keap1 and S349 phosphorylated p62 inhibitor, with an IC 50 of 1.5 microM. K67 has a weaker inhibitory effect on the interaction between Keap1 and Nrf2 (IC 50 is 6.2 microM). K67 competitively binds to the binding site of Keap1 with p-p62, blocking the abnormal activation of the p62-dependent Nrf2 pathway. K67 inhibits tumor cell proliferation and enhances the sensitivity of hepatocellular carcinoma (HCC) to chemotherapeutic drugs by restoring Keap1-mediated ubiquitination and degradation of Nrf2 [1] [2] .

CC(CC1=CC(NS(C2=CC=C(OCC)C=C2)(=O)=O)=C3C=CC=CC3=C1NS(C4=CC=C(OCC)C=C4)(=O)=O)=O

-20°C,2°C to 8°C

12352200