K777 (tosylate)
HY-119293A
Molecular Weight746.94
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameK777 (tosylate)
- Delivery Days Customer9
- CertificationResearch Use Only
- Molecular FormulaC39H46N4O7S2
- Molecular Weight746.94
- Scientific DescriptionK777 tosylate is a potent, orally active and irreversible cysteine protease inhibitor. K777 tosylate is also a potent CYP3A4 inhibitor with an IC 50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 tosylate irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi , and cathepsins B and L . K777 tosylate is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 tosylate inhibits SARS-CoV and EBOV pseudovirus entry with IC 50 values of 0.68 nM and 0.87 nM, respectively [1] [2] [3] .
- SMILESO=S(O)(C1=CC=C(C=C1)C)=O.O=S(/C=C/[C@H](CCC2=CC=CC=C2)NC([C@@H](NC(N3CCN(CC3)C)=O)CC4=CC=CC=C4)=O)(C5=CC=CC=C5)=O
- UNSPSC12352200