Kartogenin

MedChem Express

Kartogenin [4727-31-5]

10

4727-31-5

Research Use Only

98.45

C20H15NO3

317.34

Kartogenin (KGN) is an inducer of chondrogenic tissue formation ( EC 50 : 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFbeta), and by modulating the CBFbeta-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research [1] [2] [3] [4] .

O=C(O)C1=CC=CC=C1C(NC2=CC=C(C3=CC=CC=C3)C=C2)=O

-20°C,2°C to 8°C

12352200