KCNQ5 antibody

GeneTex

KCNQ5 antibody

9

This antibody is specific for KCNQ5 and does not detect KCNQ1, KCNQ2, KCNQ3 or KCNQ4.

Western Blot, ImmunoHistoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Kcnq5

potassium voltage-gated channel subfamily Q member 5

Kcnq5l; potassium channel, voltage-gated KQT-like subfamily Q, member 5; potassium voltage-gated channel subfamily KQT member 5; potassium voltage-gated channel, KQT-like subfamily, member 5

Rabbit

IgG

KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system. Studies have shown that KCNQ3 and KCNQ5 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy. Voltage-dependent potassium channels are key regulators of the resting membrane potential and modulate the excitability of electrically active cells. The channels are usually tetrameric and can interact with auxiliary subunits that enhance or modify currents mediated by the pore-forming subunits.

Human, Rat

2°C to 8°C,-20°C or -80°C

12352203