KDM2A Polyclonal Antibody

Reddot Biotech

KDM2A Polyclonal Antibody

5

1.74 mg/ml

KDM2A

lysine demethylase 2A

[Histone-H3]-lysine-36 demethylase 1A; CXXC8; CXXC-type zinc finger protein 8; FBL11; FBL7; F-box and leucine-rich repeat protein 11; F-box/LRR-repeat protein 11; FBXL11; JHDM1A; jmjC domain-containing histone demethylation protein 1A; jumonji C domain-containing histone demethylase 1A; LILINA; lysine (K)-specific demethylase 2A; lysine-specific demethylase 2A

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.

-20°C

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