KDM3A antibody

Biorbyt

KDM3A antibody

16

Western Blot

WB:1:1000-1:3000 WB

Research Use Only

Polyclonal

Unconjugated

KDM3A

lysine demethylase 3A

[histone H3]-dimethyl-L-lysine(9) demethylase 3A; JHDM2A; JHMD2A; jmjC domain-containing histone demethylation protein 2A; JMJD1; JMJD1A; jumonji C domain-containing histone demethylase 2A; jumonji domain-containing protein 1A; lysine (K)-specific demethylase 3A; lysine-specific demethylase 3A; testis-specific protein A; TSGA

Rabbit

Lysine-specific demethylase 3A

Rabbit polyclonal to KDM3A.Lysine-specific histone demethylase 3A (KDM3A) is a histone demethylase that specificallydemethylates Lys-9 of histone H3, thereby playing a central role in histone code. KDM3Apreferentially demethylates mono-and dimethylated H3 Lys-9 residue, with a preference fordimethylated residue, while it has weak or no activity on trimethylated H3 Lys-9. KDM3A is involvedin hormone-dependent transcriptional activation, by participating in recruient to androgen-receptortarget genes, resulting in H3 Lys-9 demethylation and transcriptional activation. KDM3A has beenimplicated in spermatogenesis by regulating expression of target genes such as PRM1 and P1,which are required for packaging and condensation of sperm chromatin. KDM3A is also involved inobesity resistance through regulation of metabolic genes such as PPARA and UCP1.

Human

-20°C

12352203