Kdo2-Lipid A (ready-to-use) [123621-04-5]

AdipoGen Life Sciences

Kdo2-Lipid A (ready-to-use)

10

123621-04-5

Research Use Only

0.5 mg/ml

Liquid

Warning

C110H198N2Na4O39P2

2326.7

Chemical. CAS: 123621-04-5 (free base). Formula: C110H198N2Na4O39P2. MW: 2326.7. Isolated and purified from E. coli K12 heptose-deficient strain WBB06 (Re mutant). Defined substructure of the Re mutant of lipopolysaccharide (LPS). Endotoxin activity equal to Re LPS. Strong activator (<10ng/ml) of macrophages via toll-like receptor 4 (TLR4). Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice by IL-6 ELISA. Facilitates the structural analysis of its complexes with signaling receptors, such as TLR4/MD2 and CD14. Kdo2-Lipid A was used in a recent animal atherosclerosis model. Induces sphingolipid biosynthesis, which is essential for induction of autophagy. - Defined substructure of the Re mutant of lipopolysaccharide (LPS) [1]. Endotoxin activity equal to Re LPS [1]. Strong activator (<10ng/ml) of macrophages via toll-like receptor 4 (TLR4) [1, 2, 3, 4, 9]. Does not activate TLR2 [5] or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice by IL-6 ELISA [1,4]. Facilitates the structural analysis of its complexes with signaling receptors, such as TLR4/MD2 [1,2] and CD14 [7]. Kdo2-Lipid A was used in a recent animal atherosclerosis model [6]. Induces sphingolipid biosynthesis, which is essential for induction of autophagy [8].

[Na+].[Na+].[Na+].[Na+].CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)OC1[C@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@H](OCC2O[C@H](OP(O)([O-])=O)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)C(OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H]2O)OC(CO[C@@]2(CC(O[C@@]3(CC(O)[C@@H](O)C(O3)[C@@H](O)CO)C([O-])=O)[C@@H](O)C(O2)[C@@H](O)CO)C([O-])=O)[C@H]1OP(O)([O-])=O

2°C to 8°C

12352200