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KDOAM-25 citrate
T11750
CAS Number2448475-08-7
Product group Chemicals
Molecular Weight499.51
Overview
- SupplierTargetMol Chemicals
- Product NameKDOAM-25 citrate
- Delivery Days Customer10
- CAS Number2448475-08-7
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameKDOAM-25 citrate
- Molecular FormulaC21H33N5O9
- Molecular Weight499.51
- Scientific DescriptionKDOAM-25 citrate is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC 50 s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. Multiple myeloma MM1S cells treated with KDOAM-25 citrate show increased global H3K4 methylation at transcriptional start sites and impaired proliferation [1].
- Shelf life instruction3 years
- SMILESNC(C1=CC=NC(CNCC(N(CC)CCN(C)C)=O)=C1)=O.OC(CC(C(O)=O)(O)CC(O)=O)=O
- Storage Instruction-20°
- UNSPSC12352200
References
- Tumber A, et al. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol. 2017 Mar 16;24(3):371-380.Read more