CgoaEGY7P9SEXTDjAAAAAGjtZmg371.png
CgoaEGY7P9SEXTDjAAAAAGjtZmg371.png
KDOAM-25 trihydrochloride (2230731-99-2 free base)
T11750L
Molecular Weight416.77
Product group Chemicals
Overview
- SupplierTargetMol Chemicals
- Product NameKDOAM-25 trihydrochloride (2230731-99-2 free base)
- Delivery Days Customer999
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameKDOAM-25 trihydrochloride (2230731-99-2 free base)
- Molecular FormulaC15H28Cl3N5O2
- Molecular Weight416.77
- Scientific DescriptionKDOAM-25 trihydrochloride increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells. KDOAM-25 trihydrochloride is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively.
- Shelf life instruction3 years
- SMILESNC(C1=CC=NC(CNCC(N(CC)CCN(C)C)=O)=C1)=O.Cl.Cl.Cl
- Storage Instruction-20°
- UNSPSC12352200
References
- Tumber A, et al. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol. 2017 Mar 16;24(3):371-380.Read more