Keap1-Nrf2-IN-24

MedChem Express

Keap1-Nrf2-IN-24

9

Research Use Only

C32H25FN4O5S

596.63

Keap1-Nrf2-IN-24 (compound 57) is a potent Keap1-Nrf2 inhibitor with a Ki value of 13 nM. Keap1-Nrf2-IN-24 increases the protein expression of TRXR1 and NQO1. Keap1-Nrf2-IN-24 increases the AKR1B10 mRNA expression. Keap1-Nrf2-IN-24 shows good metabolic stability[1].

O=C(C(NC(C1=CC=CC2=C1C3=C(C=CC=C3)N2C)=O)C4=CC5=C(CCN(C5)S(=O)(C6=CC=C(C(C#N)=C6)F)=O)C=C4)O

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