Keap1-Nrf2-IN-8
HY-146578
Molecular Weight706.76
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameKeap1-Nrf2-IN-8
- Delivery Days Customer10
- CertificationResearch Use Only
- Molecular FormulaC35H31FN2O9S2
- Molecular Weight706.76
- Scientific DescriptionKeap1-Nrf2-IN-8 (compound 12d) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with IC50s of 64.5 nM and 14.2 nM for FP and TR-FRET assays, respectively. Keap1-Nrf2-IN-8 significantly increases the mRNA levels of Nrf2 downstream genes, GSTM3, HMOX2 and NQO1.
- SMILESCC1=CC=C(C=C1)S(=O)(N(C2=C3C=CC=CC3=C(C(OCC4=CC=C(C=C4)F)=C2)N(S(=O)(C5=CC=C(C=C5)C)=O)CC(O)=O)CC(O)=O)=O
- Storage InstructionSee Manual
- UNSPSC12352200