KGA-2727

AbMole BioScience

KGA-2727

9

666842-36-0

Chemical

Research Use Only

C26H40N4O8

536.62

KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models.

CC(C)C1=C(CC2=C(C)C=C(OCCCNCCC(N)=O)C=C2)C(=N[NH]1)OC3OC(CO)C(O)C(O)C3O

12352200