Immunohistochemistry of paraffin-embedded Human Plasmacytoma using KI67 Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human Plasmacytoma using KI67 Monoclonal Antibody at dilution of 1:200.
Ki 67 Monoclonal Antibody
E-AB-22027
Product group Antibodies
Overview
- SupplierElabscience
- Product NameKi 67 Monoclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionRequired to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
- UNSPSC12352203