Ki20227 [623142-96-1]

Biorbyt

Ki20227 [623142-96-1]

16

623142-96-1

Research Use Only

C24H24N4O5S

480.5362

Ki-20227 is a highly selective c-Fms tyrosine kinase(CSF1R) inhibitor with IC50 value of 2 nM; 6 fold and > 100 fold selectivity over VEGFR2(IC50=12 nM) and c-Kit/PDGFR_beta_(IC50=451/217 nM), respectively.

S1C([H])=C([H])N=C1C([H])(C([H])([H])[H])N([H])C(N([H])C1C([H])=C([H])C(=C([H])C=1OC([H])([H])[H])OC1C([H])=C([H])N=C2C([H])=C(C(=C([H])C=12)OC([H])([H])[H])OC([H])([H])[H])=O

12352200