KIR2DL5B antibody

GeneTex

KIR2DL5B antibody

9

ICC/IF: 1:100~1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, ImmunoCytoChemistry

Research Use Only

Polyclonal

Unconjugated

KIR2DL5B

killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B

CD158 antigen-like family member F2; killer cell immunoglobulin-like receptor 2DL5; killer cell immunoglobulin-like receptor 2DL5B; killer cell immunoglobulin-like receptor 2DLX; killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 5; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5B; killer Ig receptor; killer-cell Ig-like receptor; KIR2DL5; KIR2DL5.2; KIR2DLX

Rabbit

IgG

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

Human

-20°C or -80°C,2°C to 8°C

12352203