KLHL12 Antibody, FITC conjugated

Cusabio

KLHL12 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

Liquid

KLHL12

kelch like family member 12

C3IP1; CUL3-interacting protein 1; DKIR; DKIR homolog; kelch-like protein 12; kelch-like protein C3IP1

Rabbit

IgG

Kelch-like protein 12

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.

Human

-20°C or -80°C

12352203