KLHL3 Polyclonal Antibody

Reddot Biotech

KLHL3 Polyclonal Antibody

5

Western Blot

Research Use Only

1 mg/ml

Unconjugated

KLHL3

kelch like family member 3

kelch-like protein 3; PHA2D

Rabbit

IgG

This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Human, Mouse

-20°C

12352203