KRAS inhibitor-13

MedChem Express

KRAS inhibitor-13

10

Research Use Only

C25H19ClFN3O2S

479.95

KRAS inhibitor-13 (compound 5-6) is a potent KRAS G12C inhibitor with an IC 50 of 0.883 microM. KRAS inhibitor-13 shows p-ERK inhibition activities with IC 50 s of 5.9, >100 microM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-13 has the potential for the research of pancreatic, colorectal, and lung cancers [1] .

C=CC(N1[C@]2([H])[C@@](CC1)([H])N(C3=C4C(C(F)=C(C5=CC(O)=CC6=C5C=CC=C6)C(Cl)=C4)=NS3)C2)=O

12352200