Bio-Connect

KRASG12C IN-14

Research Use Only
HY-168013
MedChem Express
Molecular Weight1088.24
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    KRASG12C IN-14
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Molecular Formula
    C51H65F4N9O9S2
  • Molecular Weight
    1088.24
  • Scientific Description
    KRASG12C IN-14 (compound 15) is an inhibitor targeting the KRAS G12C mutation. KRASG12C IN-14 inhibits CYPA-dependent KRAS-BRAF with an IC50 of 0.002 microM. KRASG12C IN-14 inhibits ERK phosphorylation in NCI-H358 cells with an IC50 of 0.002 microM[1].
  • SMILES
    O=C(OCC(C)(C)CC1=[C@@]([C@@]2=C([C@@H](OC)C)N=CC(N3CCOCC3)=C2)N(CC(F)(F)F)C4=C1C=C5C=C4)[C@H]6NN(C([C@@H](NC([C@H](C(C)C)N(C(N7CC(/C=C(S(C)(=O)=O)\F)C7)=O)C)=O)CC8=NC5=CS8)=O)CCC6
  • UNSPSC
    12352200