KRIT1 Polyclonal Antibody

Reddot Biotech

KRIT1 Polyclonal Antibody

5

ImmunoFluorescence

Research Use Only

1 mg/ml

Unconjugated

KRIT1

KRIT1 ankyrin repeat containing

ankyrin repeat-containing protein Krit1; CAM; CCM1; cerebral cavernous malformations 1 protein; krev interaction trapped 1; krev interaction trapped protein 1

Rabbit

IgG

This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.

Human, Mouse, Rat

-20°C

12352203