Bio-Connect

KRIT1 Polyclonal Antibody

RD267797A
Reddot Biotech
ApplicationsImmunoFluorescence
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetKRIT1
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    KRIT1 Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    ImmunoFluorescence
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID889
  • Target name
    KRIT1
  • Target description
    KRIT1 ankyrin repeat containing
  • Target synonyms
    ankyrin repeat-containing protein Krit1; CAM; CCM1; cerebral cavernous malformations 1 protein; krev interaction trapped 1; krev interaction trapped protein 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203