KRIT1 Polyclonal Antibody
RD267797A
ApplicationsImmunoFluorescence
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetKRIT1
Overview
- SupplierReddot Biotech
- Product NameKRIT1 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsImmunoFluorescence
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID889
- Target nameKRIT1
- Target descriptionKRIT1 ankyrin repeat containing
- Target synonymsankyrin repeat-containing protein Krit1; CAM; CCM1; cerebral cavernous malformations 1 protein; krev interaction trapped 1; krev interaction trapped protein 1
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203