KRT15 Antibody / Cytokeratin 15
ORB606907
ReactivityHuman
Product group Antibodies
TargetKRT15
Overview
- SupplierBiorbyt
- Product NameKRT15 Antibody / Cytokeratin 15
- Delivery Days Customer16
- Application Supplier NoteOptimal dilution of the Cytokeratin 15 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
- Applications SupplierFlow cytometry: 1-2ug/million cells,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT FACS, IHC-P
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDKRT15/2554
- ConjugateUnconjugated
- Gene ID3866
- Target nameKRT15
- Target descriptionkeratin 15
- Target synonymsCK15; CK-15; cytokeratin 15; K15; K1CO; keratin 15, type I; keratin, type I cytoskeletal 15; keratin-15, basic; keratin-15, beta; type I cytoskeletal 15
- HostMouse
- IsotypeIgG2b
- Protein IDP19012
- Protein NameKeratin, type I cytoskeletal 15
- Scientific DescriptionKeratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.
- ReactivityHuman
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203