Bio-Connect

KRT15 Antibody / Cytokeratin 15

ORB606907
Biorbyt
ReactivityHuman
Product group Antibodies
TargetKRT15
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Overview

  • Supplier
    Biorbyt
  • Product Name
    KRT15 Antibody / Cytokeratin 15
  • Delivery Days Customer
    16
  • Application Supplier Note
    Optimal dilution of the Cytokeratin 15 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
  • Applications Supplier
    Flow cytometry: 1-2ug/million cells,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT FACS, IHC-P
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    KRT15/2554
  • Conjugate
    Unconjugated
  • Gene ID3866
  • Target name
    KRT15
  • Target description
    keratin 15
  • Target synonyms
    CK15; CK-15; cytokeratin 15; K15; K1CO; keratin 15, type I; keratin, type I cytoskeletal 15; keratin-15, basic; keratin-15, beta; type I cytoskeletal 15
  • Host
    Mouse
  • Isotype
    IgG2b
  • Protein IDP19012
  • Protein Name
    Keratin, type I cytoskeletal 15
  • Scientific Description
    Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.
  • Reactivity
    Human
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203