KU-177 [1160952-43-1]

MedChem Express

KU-177 [1160952-43-1]

10

1160952-43-1

Research Use Only

C27H23NO8

489.47

KU-177 is a potent inhibitor of Hsp90 ATPase homologue 1 (Aha1), ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation. KU-177 also disrupts Aha1/Hsp90 interactions (IC50=4.08 microM) without inhibition of Hsp90s ATPase activity. KU-177 can be used for tauopathies research[1][2].

COC1=CC(C2=C(C=CC(C(NC3=CC4=CC=C(C(OC)=C4OC3=O)OC(C)=O)=O)=C2)OC)=CC=C1

12131703