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ProductsBack/Ku70 + Ku80 antibody [162]
The data was published in the journal Nucleic Acids Res in 2014.PMID: 24589584
The data was published in the journal Nucleic Acids Res in 2014.PMID: 24589584
The data was published in the journal Nucleic Acids Res in 2014.PMID: 24589584

Ku70 + Ku80 antibody [162]

GTX23108
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Monkey, Mouse, Rat, Xenopus
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Overview

  • Supplier
    GeneTex
  • Product Name
    Ku70 + Ku80 antibody [162]
  • Delivery Days Customer
    9
  • Application Supplier Note
    Flow Cytometry / Immunofluorescence: assay dependent. Immunoprecipitation (with protein A): use at a concentration of 2microg/mg protein lysate. Immunohistology (formalin fixed paraffin embedded): use at a concentration 1 - 2microg/ml for 30 min at RT (antigen retrieval is not required). Optimal dilutions / concentrations should be determined by the end user. This antibody is not suitable for Western blot.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    162
  • Concentration
    0.2 mg/ml
  • Conjugate
    Unconjugated
  • Host
    Mouse
  • Isotype
    IgG2a
  • Scientific Description
    The Ku autoantigen is a heterodimer of 70 kDa (p70) and ~80 kDa (p80) proteins. The p70 / p80 dimer is important for function of a 460 kDa DNA-dependent protein kinase that phosphorylates certain transcription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
  • Reactivity
    Human, Monkey, Mouse, Rat, Xenopus
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Additive effect of radiosensitization by 2-deoxy-D-glucose delays DNA repair kinetics and suppresses cell proliferation in oral squamous cell carcinoma. Kawata M et al., 2017 Nov, J Oral Pathol Med
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  • A novel cytoprotective function for the DNA repair protein Ku in regulating p53 mRNA translation and function. Lamaa A et al., 2016 Apr, EMBO Rep
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  • Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM. Maiti AK et al., 2014 Aug 1, Hum Mol Genet
    Read more
  • Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair. Morales JC et al., 2014 Apr, Nucleic Acids Res
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  • Novel regulatory role for Kaposis sarcoma-associated herpesvirus-encoded vFLIP in chemosensitization to bleomycin. Masuda Y et al., 2011 Nov 18, Biochem Biophys Res Commun
    Read more