L 668411

MedChem Express

L 668411

9

Research Use Only

C19H30O5

338.44

L 668411 is a beta-lactone inhibitor with activity against 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis. L 668411 inhibits rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase and [14C] acetate incorporation into sterols in cultured Hep G2 cells, and the inhibition appears to be irreversible in cells but reversible in cultured cells and animals.

COC(/C=C(C)/C=C(C)/C[C@H](C)CCCC[C@@H]1[C@H](C(O1)=O)CO)=O

12352200