L-732138

MedChem Express

L-732138 [148451-96-1]

5

148451-96-1

99.9

C22H18F6N2O3

472.38

L-732138 is a selective, potent and competitive neurokinin-1 (NK-1) receptor antagonist with an IC 50 of 2.3 nM. L-732138 has 200-fold more potent in cloned human NK-1 receptors than cloned rat NK-1 receptors , and has > 1000-fold more potent than human NK-2 and NK-3 receptors. L-732138 can reduce hyperalgesia and has antitumor action [1] [2] .

O=C(OCC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)[C@H](CC2=CNC3=CC=CC=C23)NC(C)=O

-20°C,2°C to 8°C

12352200