L 741742

MedChem Express

L 741742

9

Research Use Only

C23H25ClN2O

380.91

L 741742 is a dopamine receptor D4 ( DRD4 ) antagonist that selectively inhibits glioblastomas (GBM) growth in vitro and in vivo, synergyed with Temozolomide (TMZ) (HY-17364). L 741742 disrupts in effectors PDGFRbeta/ERK1/2 and mTOR signaling. Additionally, L 741742 disrupts endolysosmal function compromising the autophagy-lysosomal degradation pathway, followed by G0/G1 cell cycle arrest and Apoptosis . L 741742 is promising for research of GBM and neurogenesis [1] .

CC1=C(C2=CC=C(Cl)C=C2)ON=C1C3CCN(CCC4=CC=CC=C4)CC3

12352200