L-Asparagine-13C4,15N2 (monohydrate)
HY-W017443S
Overview
- SupplierMedChem Express
- Product NameL-Asparagine-13C4,15N2 (monohydrate) [202406-87-9]
- Delivery Days Customer10
- CAS Number202406-87-9
- CertificationResearch Use Only
- Estimated Purity98.0
- Molecular Formula13C4H10 15N2O4
- Molecular Weight156.09
- Scientific DescriptionL-Asparagine-13C4,15N2 monohydrateis the 13C-labeled and 15N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5][6].
- SMILES[15NH2][13C@]([13C](O)=O)[13C][13C]([15NH2])=O.[H]O[H]
- Storage Instruction2°C to 8°C
- UNSPSC12352200