L-Asparagine-amide-15N (monohydrate)

MedChem Express

L-Asparagine-amide-15N (monohydrate) [204451-47-8]

10

204451-47-8

Research Use Only

99.80

C4H10N 15NO4

151.13

L-Asparagine-amide-15N monohydrate is the 15N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5][6].

[15NH2]C(C[C@H](N)C(O)=O)=O.[H]O[H]

2°C to 8°C

12352200