L002

MedChem Express

L002 [321695-57-2]

10

321695-57-2

99.44

C15H15NO5S

321.35

L002 is a potent, cell permeable, reversible and specific acetyltransferase p300 (KAT3B) inhibitor with an? IC 50 ?of 1.98 microM [1] . L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation [2] . L002 has the potential for hypertension-induced cardiac hypertrophy and fibrogenesis treatment [3] .

O=C1C(C)=C/C(C=C1C)=N\OS(=O)(C2=CC=C(OC)C=C2)=O

-20°C,2°C to 8°C

12352200