L1CAM Antibody / NCAM-L1 / CD171

Biorbyt

L1CAM Antibody / NCAM-L1 / CD171

16

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.

ELISA

ELISA (order BSA/sodium azide-free format for coating) ELISA

Research Use Only

Monoclonal

UJ127

Unconjugated

L1CAM

L1 cell adhesion molecule

antigen identified by monoclonal antibody R1; CAML1; CD171; HSAS; HSAS1; MASA; MIC5; N-CAML1; N-CAM-L1; NCAM-L1; neural cell adhesion molecule L1; S10; SPG1

Mouse

IgG1

Neural cell adhesion molecule L1

This antibody recognizes a cell surface protein of 220-240kDa, identified as L1CAM (L1 cell adhesion molecule). The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs); and 3) SPG1 (spastic paraplegia). L1CAM also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. antibody to L1CAM is useful in the identification of primitive neuroectodermal tumors. The antibody binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.

Human

-20°C,2°C to 8°C

12352203