Bio-Connect

L6H21

HY-W082785A
MedChem Express
Estimated Purity99.46
Product group Chemicals
Molecular Weight298.34
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Overview

  • Supplier
    MedChem Express
  • Product Name
    L6H21
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    99.46
  • Molecular Formula
    C18H18O4
  • Molecular Weight
    298.34
  • Scientific Description
    L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 ( MD-2 ) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low K D value of 33.3?microM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-alpha and IL-6 in RAW264.7 macrophages, with IC 50 values of 6.58 and 8.59 microM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research [1] [2] [3] .
  • SMILES
    O=C(C1=CC=C(OC)C=C1)/C=C/C2=CC=CC(OC)=C2OC
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200