L6H21

MedChem Express

L6H21

10

Research Use Only

99.46

C18H18O4

298.34

L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 ( MD-2 ) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low K D value of 33.3?microM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-alpha and IL-6 in RAW264.7 macrophages, with IC 50 values of 6.58 and 8.59 microM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research [1] [2] [3] .

O=C(C1=CC=C(OC)C=C1)/C=C/C2=CC=CC(OC)=C2OC

-20°C,2°C to 8°C

12352200