LAMP3 / CD208 Antibody (clone LAMP3/529)

LifeSpan BioSciences

LAMP3 / CD208 Antibody (clone LAMP3/529)

23

Human LAMP3 / CD208

This mAb recognizes protein of 26kDa-60kDa, which is identified as CD63/LAMP3. Its epitope is different from that of mAb LAMP3/803 or LAMP3/968 or NKI/C3 or MX-49.129.5. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63/LAMP3 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. It is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63/LAMP3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression. Optimal dilution of the LAMP3 antibody should be determined by the researcher.. Flo (0.5 - 1 µg/10E6 cells), IF (0.5 - 1 µg/ml) This mAb recognizes protein of 26kDa-60kDa, which is identified as CD63/LAMP3. Its epitope is different from that of mAb LAMP3/803 or LAMP3/968 or NKI/C3 or MX-49.129.5. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63/LAMP3 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. It is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63/LAMP3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression. Optimal dilution of the LAMP3 antibody should be determined by the researcher.

Flow Cytometry, ImmunoFluorescence

Research Use Only

Monoclonal

LAMP3/529

0.2 mg/ml

Unconjugated

...

LAMP3

lysosomal associated membrane protein 3

CD208; DC LAMP; DCLAMP; DC-LAMP; DC-lysosome-associated membrane glycoprotein; LAMP; LAMP-3; lysosome-associated membrane glycoprotein 3; TSC403

Mouse

IgG2a

Human

-20°C,2°C to 8°C

12352203