Langerin / CD207 (Marker of Langerhans Cells)(LGRN/3136R), CF594 conjugate, 0.1mg/mL [26628-22-8]

Biotium

Langerin / CD207 (Marker of Langerhans Cells)(LGRN/3136R), CF594 conjugate, 0.1mg/mL

9

Research Use Only

Monoclonal

LGRN/3136R

0.1 mg/ml

Other Conjugate

CD207

CD207 molecule

CD207 antigen, langerin; CD207 molecule, langerin; CLEC4K; C-type lectin domain family 4 member K; C-type lectin domain family 4, member K; Langerhans cell specific c-type lectin

Rabbit

IgG

C-type lectin domain family 4 member K

Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2 -dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Human

2°C to 8°C

12352203