LC3B antibody
GTX127375
ApplicationsElectron Microscopy, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityGuinea Pig, Human, Insect, Mouse, Porcine, Rat
TargetMAP1LC3B
Overview
- SupplierGeneTex
- Product NameLC3B antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. FACS: 1:50-1:200. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsElectron Microscopy, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.34 mg/ml
- ConjugateUnconjugated
- Gene ID81631
- Target nameMAP1LC3B
- Target descriptionmicrotubule associated protein 1 light chain 3 beta
- Target synonymsATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a, microtubule-associated protein 1 light chain 3 beta, MAP1 light chain 3-like protein 2, MAP1A/MAP1B LC3 B, MAP1A/MAP1B light chain 3 B, autophagy-related ubiquitin-like modifier LC3 B, microtubule-associated proteins 1A/1B light chain 3B
- HostRabbit
- IsotypeIgG
- Protein IDQ9GZQ8
- Protein NameMicrotubule-associated protein 1 light chain 3 beta
- Scientific DescriptionThe product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq]
- ReactivityGuinea Pig, Human, Insect, Mouse, Porcine, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- El-Gamal R, Elfarrash S, El-Nablaway M, et al. Anti-proliferative activity of RIHMS-Qi-23 against MCF-7 breast cancer cell line is through inhibition of cell proliferation and senescence but not inhibition of targeted kinases. BMC Cancer. 2023,23(1):1053. doi: 10.1186/s12885-023-11547-1Read this paper
- Chittineedi P, Pandrangi SL, Neira Mosquera JA, et al. Aqueous Nyctanthes arbortristis and doxorubicin conjugated gold nanoparticles synergistically induced mTOR-dependent autophagy-mediated ferritinophagy in paclitaxel-resistant breast cancer stem cells. Front Pharmacol. 2023,14:1201319. doi: 10.3389/fphar.2023.1201319Read this paper
- Cardile A, Passarini C, Zanrè V, et al. Hyperforin Enhances Heme Oxygenase-1 Expression Triggering Lipid Peroxidation in BRAF-Mutated Melanoma Cells and Hampers the Expression of Pro-Metastatic Markers. Antioxidants (Basel). 2023,12(7). doi: 10.3390/antiox12071369Read this paper
- Hwang TI, Cuiu YC, Chen YC, et al. Tumor suppressive functions of hsa‑miR‑34a on cell cycle, migration and protective autophagy in bladder cancer. Int J Oncol. 2023,62(5):pii: 66. doi: 10.3892/ijo.2023.5514.Read this paper
- Chiou HC, Wang CW, Chen SC, et al. Copper Exposure Induces Epithelial-Mesenchymal Transition-Related Fibrotic Change via Autophagy and Increase Risk of Lung Fibrosis in Human. Antioxidants (Basel). 2023,12(2). doi: 10.3390/antiox12020532Read this paper
- Han YJ, Lee KM, Wu GH, et al. Targeting influenza A virus by splicing inhibitor herboxidiene reveals the importance of subtype-specific signatures around splice sites. J Biomed Sci. 2023,30(1):10. doi: 10.1186/s12929-023-00897-4Read this paper
- Cardile A, Zanrè V, Campagnari R, et al. Hyperforin Elicits Cytostatic/Cytotoxic Activity in Human Melanoma Cell Lines, Inhibiting Pro-Survival NF-κB, STAT3, AP1 Transcription Factors and the Expression of Functional Proteins Involved in Mitochondrial and Cytosolic Metabolism. Int J Mol Sci. 2023,24(2). doi: 10.3390/ijms24021263Read this paper
- Li J, Zha X, Kang Y, et al. Oxygen-carrying sequential preservation mitigates liver grafts ischemia-reperfusion injury. iScience. 2023,26(1):105858. doi: 10.1016/j.isci.2022.105858Read this paper
- Sapienza S, Tedeschi V, Apicella B, et al. Size-Based Effects of Anthropogenic Ultrafine Particles on Lysosomal TRPML1 Channel and Autophagy in Motoneuron-like Cells. Int J Mol Sci. 2022,23(21). doi: 10.3390/ijms232113041Read this paper
- Wen Y, Chen Z, Tian Y, et al. Incomplete autophagy promotes the proliferation of Mycoplasma hyopneumoniae through the JNK and Akt pathways in porcine alveolar macrophages. Vet Res. 2022,53(1):62. doi: 10.1186/s13567-022-01074-5Read this paper
Datasheet
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![ICC/IF analysis of PFA-fixed C6 cells with/without Chloroquine (50 microM, 37oC, 20 hrs) treatment using GTX00949 LC3B antibody [GT1187]. Right : untreated C6 cells Left : C6 cells with 50 microM Chloroquine (20 hrs, 37oC) treatment Orange : Primary antibody Blue : DAPI Dilution : 1:100](https://www.genetex.com/upload/website/prouct_img/normal/GTX00949/GTX00949_20200327_ICC-IF_42_w_23053121_487.webp)
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