LDHA-IN-8

MedChem Express

LDHA-IN-8

9

Research Use Only

C15H14N4O2

282.30

LDHA-IN-8 (Compound 6) is a lactate dehydrogenase (LDHA) inhibitor. LDHA-IN-8 inhibits LDHA catalysis of pyruvate in a dose-dependent manner (EC50 value of 14.54 microM), reduces intracellular lactate levels, and increases intracellular reactive oxygen species (ROS) levels, thereby inhibiting the proliferation of pancreatic cancer cells and lung cancer cells. LDHA-IN-8 holds promise for research in the field of LDHA-related antitumor therapies[1].

CC1=CC(/C=C2C(NC(N/2)=O)=O)=C(C)N1C3=CN=CC=C3

12352200