LECT1 Polyclonal Antibody

Reddot Biotech

LECT1 Polyclonal Antibody

5

ImmunoFluorescence

Research Use Only

1 mg/ml

Unconjugated

CNMD

chondromodulin

BRICD3; BRICHOS domain containing 3; CHM1; CHM-I; chondromodulin-1; chondromodulin-I; LECT1; leukocyte cell derived chemotaxin 1; leukocyte cell-derived chemotaxin 1; multiple myeloma tumor suppressor 1; MYETS1

Rabbit

IgG

This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.

Human, Mouse

-20°C

12352203