Legumain antibody [46I3]

GeneTex

Legumain antibody [46I3]

9

WB: 1:500 - 1:1000. ELISA: 1:1000 - 1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA

Research Use Only

Monoclonal

46I3

200 ug/ml

Unconjugated

LGMN

legumain

AEP; asparaginyl endopeptidase; cysteine protease 1; legumain; LGMN1; protease, cysteine 1; protease, cysteine, 1 (legumain); PRSC1

Mouse

IgG1

Legumain

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]

Human

-20°C or -80°C,2°C to 8°C

12352203