LEI110

MedChem Express

LEI110

10

Research Use Only

99.72

C25H23F3N2O3

456.46

LEI110 is a potent, selective and cell-permeable pan-inhibitor of the HRASLS family of thiol hydrolases. LEI110 inhibits PLA2G16, HRASLS2, RARRES3 and iNAT, with pIC50 values of 7.0, 6.8, 6.8, and 7.6, respectively. LEI110 reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in HepG2 cells[1].

O=C(NCCC1=CC=C(OC2=NC=C(C(F)(F)F)C=C2)C=C1)C(CCCC3=CC=CC=C3)=O

-20°C,2°C to 8°C

12352200