LEI110

MedChem Express

LEI110

10

Research Use Only

99.94

C25H23F3N2O3

456.46

LEI110 is a potent, selective and cell-permeable pan-inhibitor of the HRASLS family of thiol hydrolases. LEI110 inhibits PLA2G16 , HRASLS2 , RARRES3 and iNAT , with pIC 50 values of 7.0, 6.8, 6.8, and 7.6, respectively. LEI110 reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in HepG2 cells [1] .

O=C(NCCC1=CC=C(OC2=NC=C(C(F)(F)F)C=C2)C=C1)C(CCCC3=CC=CC=C3)=O

-20°C,2°C to 8°C

12352200