Lesogaberan

MedChem Express

Lesogaberan

10

344413-67-8

C3H9FNO2P

141.08

Lesogaberan (AZD-3355) is a potent and selective GABA B receptor agonist with an EC 50 of 8.6 nM for human recombinant GABA B receptors. The affinity ( K i s) of Lesogaberan for rat GABA B and GABA A receptors, as measured by displacement of [ 3 H]GABA binding in brain membranes: 5.1 nM and 1.4 microM, respectively. Lesogaberan inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action [1] .

O=P(O)C[C@H](F)CN

12352200