Lesogaberan (napadisylate)

MedChem Express

Lesogaberan (napadisylate) [477956-38-0]

10

477956-38-0

C13H17FNO5PS

349.31

Lesogaberan (AZD-3355) napadisylate is a potent and selective GABA B receptor agonist with an EC 50 of 8.6 nM for human recombinant GABA B receptors. The affinity ( K i s) of Lesogaberan napadisylate for rat GABA B and GABA A receptors, as measured by displacement of [ 3 H]GABA binding in brain membranes: 5.1 nM and 1.4 microM, respectively. Lesogaberan napadisylate inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action [1] .

O=S(C1=CC=C2C=CC=CC2=C1)(O)=O.O=P(C[C@H](F)CN)O

12352200