[Leu144,Arg147]-PLP (139-151)

MedChem Express

[Leu144,Arg147]-PLP (139-151)

5

Research Use Only

[Leu144,Arg147]-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP), with the tryptophan and histidine at positions 144 and 147 respectively replaced by leucine and arginine. [Leu144,Arg147]-PLP (139-151) also serves as a T cell receptor ( TCR ) antagonist for encephalitogenic Th1 clones, blocking their activation in vitro . Furthermore, [Leu144,Arg147]-PLP (139-151) can inhibit the development of experimental autoimmune encephalomyelitis (EAE) [1] .

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