Leucettinib-92

MedChem Express

Leucettinib-92

14

Research Use Only

C21H22N4OS

378.49

Leucettinib-92 (compound 92) is an inhibitor of DYRK/CLK kinase, The IC50s are 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 microM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 microM (DYRK2), respectively. 1.0 microM (DYRK3), 0.52 microM (DYRK4), 2.78 microM (GSK3)[1].

O=C(N1)/C(N=C1NC2(C3)C[C@H]4C[C@@H]3C[C@@H](C2)C4)=C/C5=CC=C(N=CS6)C6=C5

12352200