LG100268

MedChem Express

LG100268 [153559-76-3]

9

153559-76-3

99.22

C24H29NO2

363.49

LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC 50 values of 4 nM, 3 nM, and 4 nM for RXR-alpha, RXR-beta, and RXR-gamma, respectively [1] . LG100268 displays >1000-fold selectivity for RXR over RAR, the K i values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-alpha, RXR-beta, and RXR-gamma, respectively [2] . LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy [3] .

O=C(C1=CC=C(C2(C3=C(C)C=C4C(C)(C)CCC(C)(C)C4=C3)CC2)N=C1)O

-20°C,2°C to 8°C

12352200